Photo-Switchable Supramolecular Glycochips for Capturing Suspension Tumor Cells and Real-Time Profiling of Cell Surface Glycosylation

Key Points

• This research aims to develop a novel platform for capturing tumor cells and analyzing their glycosylation in real time.
• Fabricated photo-switchable supramolecular glycochip via host-guest complexation.
• Utilized galactose-modified pillar[5]arene to enhance cell capture.
• Applied multivalent carbohydrate-protein interactions for effective binding.
• The glycochip successfully captured suspension tumor cells through targeted interactions.
• Real-time profiling revealed variations in cell surface glycosylation patterns.
• Enhanced sensitivity and specificity were achieved compared to traditional methods.