INTRODUCTION: To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control (<135/85 mmHg). MATERIAL AND METHODS: This was a prospective study that assessed women at presentation with hypertension and after 1 and 2 weeks of antihypertensive therapy. At each visit, blood pressure (BP) and blood tests to obtain levels of sFlt-1 and PLGF were taken. A multilevel linear mixed-effects model was performed to compare the repeated measurements of sFlt-1 and PLGF, controlling for maternal demographics, diagnosis at presentation, and antihypertensive agent used. The cohort was further subdivided into two groups based on how quickly they achieved target BP control to assess whether the degree of initial control influenced the angiogenic profile. Group 1 achieved BP < 135/85 after 1 week, while group 2 after 2 weeks of treatment. RESULTS: sFlt-1. CONCLUSIONS: sFlt-1 remaining static with time.
Tyrell et al. (Wed,) studied this question.