What is the clinical evidence from this study?

Study design: Cohort. Population: Early vascular ageing (EVA). Intervention: Early vascular ageing (EVA) escapers vs. EVA nonescapers. Primary outcome: Mean carotid intima-media thickness (cIMT) (p=0.009).

What does this research mean for the field?

Elderly individuals with early vascular ageing who escape cardiovascular events over a 10-year period have significantly lower carotid intima-media thickness compared to those who experience events, despite having comparable pulse wave velocity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to identify characteristics of elderly individuals who escape cardiovascular complications despite high arterial stiffness.

May 16, 2026

Elderly escapers from cardiovascular complications and death despite high arterial stiffness: why are they protected?

Key Result

Elderly individuals with early vascular ageing who escaped cardiovascular events over 10 years had lower mean carotid intima-media thickness than nonescapers (0.92 vs. 1.01 mm; P=0.009).

Key Points

The study aims to identify characteristics of elderly individuals who escape cardiovascular complications despite high arterial stiffness.
Analyzed data from the MARE Consortium and MDCS-CV including cardiovascular risk factors, PWV, and cIMT.
Compared EVA survivors aged 75+ years with high PWV to age-matched controls.
Evaluated EVA escapers over a 10-year follow-up period, assessing major adverse cardiovascular events and mortality.
EVA elderly survivors showed a higher overall risk factor burden compared to controls, with elevated cIMT levels.
In MDCS-CV, EVA escapers had significantly lower mean cIMT than nonescapers (0.92 vs. 1.01 mm; P=0.009) despite similar PWV (17 vs. 16 m/s).
No other significant differences were observed between the groups.

Study Design

Type

Cohort

Multicenter

Yes

Structured PICO

Population

Individuals 75+ years with early vascular ageing (EVA) defined as pulse wave velocity (PWV) ≥ 90th percentile for age strata, from the MARE Consortium and MDCS-CV cohort.

Comparator

Age-matched and sex-matched controls (PWV 0 to 75th percentile) and EVA nonescapers (who experienced MACE or death).

Outcome

Differences in cardiovascular risk factors and carotid intima-media thickness (cIMT).surrogate

Elderly individuals who survive with high arterial stiffness without cardiovascular complications are characterized by lower carotid intima-media thickness, suggesting discordant arterial ageing.

Main Result

Absolute Event Rate: 0.92% vs 1.01%

p-value: p=0.009

Abstract

Background: Individuals with high pulse wave velocity (PWV) may suffer from early vascular ageing (EVA) and face increased cardiovascular risk. Nonetheless, some individuals with EVA survive until old age, some even escaping cardiovascular complications entirely. The aim of this study was to explore characteristics of such individuals in population-based cohorts. Methods: We used data from the Metabolic syndrome and Artery REsearch (MARE) Consortium and a MARE sub-cohort; the Malmö Diet Cancer Study – Cardiovascular (MDCS-CV) arm for analyses, both covering cardiovascular risk factors, PWV, and carotid intima–media thickness (cIMT). EVA survivors (individuals 75+ years; PWV ≥ 90th percentile for age strata), were compared to age-matched and sex-matched controls (PWV 0 to 75th percentile). Additionally, in MDCS-CV, prospective EVA escapers without major adverse cardiovascular events (MACE) or death during 10-year follow-up, were compared to EVA nonescapers. Results: EVA Elderly survivors in the MARE Consortium had a higher risk factor burden, including cIMT levels, compared to controls. In MDCS-CV, similar patterns were found; however, cIMT did not differ between EVA Elderly survivors and controls, despite higher mean PWV (17 vs. 11 m/s). Finally, in MDCS-CV, EVA Elderly escapers ( n = 34) compared to nonescapers ( n = 56) had lower mean cIMT (0.92 vs. 1.01 mm; P = 0.009), despite comparable PWV (17 vs. 16 m/s). No other group differences were observed. Conclusion: EVA elderly survivors and escapers exist even among the very elderly. The latter are characterized by lower cIMT than EVA Elderly nonescapers. This could indicate discordant (differentiated) arterial ageing to be further explored.

AI से पूछें

Bookmark

Cite This Study

Nilsson et al. (Thu,) conducted a cohort in Early vascular ageing (EVA). Early vascular ageing (EVA) escapers vs. EVA nonescapers was evaluated on Mean carotid intima-media thickness (cIMT) (p=0.009). Elderly individuals with early vascular ageing who escaped cardiovascular events over 10 years had lower mean carotid intima-media thickness than nonescapers (0.92 vs. 1.01 mm; P=0.009).

synapsesocial.com/papers/6a080b84a487c87a6a40d969 https://doi.org/https://doi.org/10.1097/hjh.0000000000004348

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

AI से पूछें

Bookmark