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. In an ALI mouse model, PM@Mat-NPs selectively accumulated in inflamed lung tissue, significantly reduced pro-inflammatory cytokines (TNF-α, IL-6), and alleviated histological damage. They also suppressed NLRP3 inflammasome activation and apoptosis, outperforming free matrine. Biosafety evaluations confirmed no significant adverse effects. This study introduces a biomimetic nano-platform for the targeted delivery of Chinese herbal components, offering a promising strategy for treating acute lung injury.
Fan et al. (Tue,) studied this question.
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