Assembly of vascularized EMOs with human iPSC-derived sympathetic neuron spheroids yields innervated EMOs with integrated neurovascular organization and functional responses to nicotine stimulation.
processes. Assembly of these vascularized EMOs with human iPSC-derived sympathetic neuron spheroids yields innervated EMOs exhibiting integrated neurovascular organization and functional responses to nicotine stimulation (iV-EMOs). This modular, developmentally guided organoid system features coordinated human cardiac, vascular, and neural development, providing a physiologically relevant platform for studying heart morphogenesis, neurovascular interactions, and regenerative therapeutic strategies.
Branco et al. (Wed,) conducted a other in Embryonic heart development. Human heart organoid system (iV-EMOs) was evaluated. Assembly of vascularized EMOs with human iPSC-derived sympathetic neuron spheroids yields innervated EMOs with integrated neurovascular organization and functional responses to nicotine stimulation.