Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification

Key Points

• This study aims to evaluate the effectiveness of consensus definitions versus outcome-based classifications for acute-on-chronic liver failure.
• Comparison of consensus organ failure criteria and A-TANGO classification.
• Analysis of clinical validity of both frameworks for risk stratification.
• Identification of implications for case identification in ACLF.
• Consensus criteria showed a significantly different risk stratification compared to A-TANGO classification.
• Clinical validity of the A-TANGO classification was higher in predicting patient outcomes.
• Findings suggest the need for uniform definitions for effective management of ACLF.