Vitiligo substantially impairs health-related quality of life (HRQoL), yet the independent impact of clinical characteristics remains inconsistent across populations. Data from Afghanistan are limited despite potential sociocultural influences. This multicenter cross-sectional study evaluated independent associations of disease severity, activity, duration, and extent with HRQoL among 402 adults with clinically confirmed vitiligo in Kandahar. Disease severity was assessed using the Vitiligo Area Severity Index (VASI), along with anatomical extent and activity status. HRQoL was measured using the Dermatology Life Quality Index (DLQI). Multivariable linear regression analyses with robust standard errors were adjusted for age, sex, and psychological distress. The mean DLQI score was 5.1±3.0. VASI demonstrated a weak but statistically significant correlation with DLQI (r=0.135; p=0.007). Moreover, higher VASI scores independently predicted poorer HRQoL (β=0.071; p=0.008). Stable and repigmenting disease was associated with an approximately 1.18-point higher DLQI score compared with progressive disease (p<0.001). Disease duration and anatomical extent were not independent predictors. The model explained 18.4% of DLQI variance. Severity and activity were the principal correlates of HRQoL impairment.
Farooqi et al. (Thu,) studied this question.
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