Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report

Key Points

• To present a case of anti-LG1 antibody-positive encephalitis with memory impairment and poor response to corticosteroids.
• Described a case of a 30-year-old male with memory impairment and seizures confirmed through high-order cognitive function tests and MRI findings.
• Diagnosed with anti-LGI1 antibody-positive encephalitis after positive testing in cerebrospinal fluid.
• Treatment involved steroid therapy followed by plasma exchange and intravenous immunoglobulin therapy.
• Steroid therapy did not improve symptoms, leading to a subsequent seizure status.
• Plasma exchange and immunoglobulin therapy improved the seizure status but memory impairment and bilateral medial temporal lobe atrophy persisted.