Indole-3-carboxaldehyde from Limosilactobacillus reuteri targets the DUSP1/ERK/NOX2/ROS axis to enhance the bactericidal activity of macrophages and protects against sepsis

Key Points

• This research investigates how indole-3-carboxaldehyde from Limosilactobacillus reuteri enhances macrophage function to combat sepsis.
• Analyzed the DUSP1/ERK/NOX2/ROS pathway in macrophages exposed to indole-3-carboxaldehyde and its metabolite.
• Evaluated the immune response and bactericidal activity in macrophages following treatment.
• Indole-3-carboxaldehyde significantly increased macrophage bactericidal activity against pathogens.
• Activation of the DUSP1/ERK/NOX2/ROS axis correlated with enhanced reactive oxygen species production in treated macrophages.