Nanocomposite hydrogels with temperature-accelerated antioxidant activity for ocular applications

Key Points

• This research aims to develop a nanocomposite hydrogel that enhances antioxidant efficacy in ocular applications through temperature responsiveness.
• Developed pNIPAM–Ag/Cu@Cu nanocomposite for ocular therapy.
• Evaluated stability and transparency of the hydrogel under varying temperatures.
• Assessed antioxidant activity through LCST-mediated contraction.
• Demonstrated significant improvement in antioxidant activity at elevated temperatures.
• Hydrogel maintained stability and transparency throughout the examination period.
• Observed a clear increase in scavenging effect due to temperature responsiveness.