Abstract Nanotechnology is a rapidly growing, transformative approach in the field of male reproductive health, addressing dire challenges connected with infertility. This review explores the application of nanotechnology in enhancing sperm selection and processing, which are vital for improving reproductive outcomes in assisted reproductive technologies (ART). Traditional methods, such as swim-up assay and density gradient centrifugation, often yield variable recovery rates and may not be efficient with poor sperm samples. In contrast, innovative techniques utilizing nanoparticles, especially magnetic-activated cell sorting (MACS), demonstrate superior efficacy in selective isolation of viable sperm by targeting specific biomarkers. The unique properties of nanoparticles, including tunable size and surface charge, enhance their binding capabilities, thereby improving the precision of sperm selection.C Additionally, advancements in assisted reproductive technologies, showcase the potential of nanoparticles in sperm transport and gamete preservation. Despite the potential benefits, challenges remain, including the need for standardized protocols and addressing safety concerns associated with nanoparticle use. This review underscores the necessity for future studies to fully harness the potential of nanotechnology in overcoming male infertility, ultimately contributing to improved ART success rates and better reproductive health outcomes.
Akhigbe et al. (Fri,) studied this question.