Pituitary Crooke cell adenoma is a rare subtype of adrenocorticotropic hormone (ACTH)-producing adenoma, characterized by the presence of Crooke hyaline changes within the tumor cells . This tumor is known for its aggressive behavior and high recurrence rate, often presenting with atypical clinical manifestations that can lead to missed diagnosis . This article reports the case of a 27-year-old male patient whose initial symptom was “blurred vision in the left eye for over 1 month.” The diagnosis was confirmed by pathologic examination following endoscopic endonasal transsphenoidal surgery. This case underscores the importance of considering functional adenomas in the differential diagnosis of sellar masses even without classic endocrine symptoms. The authors herein discuss the diagnostic pitfalls, surgical strategies, and key aspects of postoperative management to improve the understanding of this aggressive variant.
Zhang et al. (Fri,) studied this question.