Reports of biological transmutation have historically occupied a difficult position between experimental anomaly, fringe interpretation, and possible overlooked boundary physics. The central objection is that ordinary biological systems do not possess the thermal energy normally required to overcome the Coulomb barrier between nuclei. This paper proposes a refined framework: bio-mediated nuclear transformation should not be understood primarily as low-energy fusion, but as a possible boundary-permeability phenomenon occurring through rare Coulomb-bridge states. The Coulomb barrier is interpreted as the electrostatic expression of a deeper Coulomb boundary separating U(1)-type atomic shell organization from SU(3)-type nuclear closure. Between these regimes lies a transitional SU(2)-like bridge layer associated with torsion, weak conversion, shell-nucleus coupling, chirality, and identity transformation. The framework distinguishes three transformation pathways: merger, capture, and conversion. It then proposes a Coulomb Bridge Functional in which transformation likelihood depends on nuclear pathway admissibility, bridge probability, biological enhancement, and coherent boundary organization. The central claim is conditional rather than absolute: biological systems do not overcome the Coulomb barrier by brute energy, but may, under rare and testable conditions, organize shell-nucleus resonance through redox gradients, proton choreography, structured water, chirality, membrane potentials, enzyme geometry, biofilms, and mineral interfaces. The paper therefore reclassifies biological transmutation as a stricter scientific question: whether isotope-specific, pathway-admissible, contamination-controlled, and reproducible bio-mediated nuclear transformations occur under identifiable Coulomb-bridge conditions. Keywords Biological transmutation; bio-mediated nuclear transformation; Coulomb barrier; Coulomb bridge; shell-nucleus resonance; isotope transformation; LENR; electron capture; nuclear boundary; infratier closure physics; U(1); SU(2); SU(3); biological coherence; biomineral interfaces.
Philip Lilien (Sat,) studied this question.