Based on the vast applications in biological and therapeutic contexts, heterocyclic compounds, particularly those containing at least one heteroatom like oxygen, sulphur, nitrogen, phosphorus, and selenium, have received increased interest in the study of their chemical properties. Apart from their crucial contributions in pharmaceutical applications, their derivatives are recognized to serve such important roles in living systems as found in photosynthesis, oxygen transport, storage, and redox cycling reactions. The goal of this review is to particularly focus on the quantitative reports on new trends in the methods of preparing simple and bulky pyrroles, their various derivatives, including metal complexes and metallacrowns, as well as their potential applications as therapeutics in medicinal chemistry for the treatment of cancer, inflammation, convulsion, diabetes, psychotic, and other chronic diseases.
Zulu et al. (Mon,) studied this question.