Key points are not available for this paper at this time.
BACKGROUND aOR, 1.24; 95% confidence interval CI, 1.21-1.28). Restricted analyses to antibiotics ≥5 years before CD diagnosis yielded an aOR of 1.15 (95% CI, 1.11-1.19). The association increased with the number of dispensations (aOR, 1.21; 95% CI, 1.17-1.25 for 1-2; 1.35; 95% CI, 1.30-1.41 for ≥3 vs none). The association between CD and prior antibiotics persisted in sibling comparisons (any use: aOR, 1.29; 95% CI, 1.24-1.35). An even stronger association with antibiotics was seen among individuals with normal mucosa (aOR, 1.50; 95% CI, 1.48-1.51), with a particularly elevated risk in those with ≥3 earlier dispensations (aOR, 1.80; 95% CI, 1.78-1.83). CONCLUSIONS: Individuals with CD were more often exposed to antibiotics before diagnosis than their general population comparators. However, an even stronger association with antibiotic use was seen in those with normal mucosa, suggesting that heightened surveillance rather than causality may contribute to the observed patterns. Although antibiotic stewardship remains important, CD concerns should not deter appropriate antibiotic use.
Ulnes et al. (Wed,) studied this question.