Key points are not available for this paper at this time.
demonstrated that the overexpression of KRT15 promoted proliferation, migration, invasion, and stemness in ESCC cells, while its knockdown suppressed these phenotypes. Clinically, high KRT15 expression was significantly associated with poorer overall survival and progression-free survival and served as an independent prognostic risk factor. Collectively, our findings indicate that KRT15 acts as a functional regulator of stemness and invasiveness in ESCC, highlighting its potential as a therapeutic target and a prognostic biomarker for postoperative risk stratification.
Xiong et al. (Wed,) studied this question.