The Need for Clarity Among the Shadows: It Is time to Further Refine the Definition of Primary Graft Dysfunction in Lung Transplant Recipients

Key Points

• The aim is to refine the definition of primary graft dysfunction (PGD) to improve clinical trial design and outcomes.
• Proposing modifications to the current definition of PGD.
• Suggesting the inclusion of objective surrogates for allograft injury.
• Advocating for a focus on diffuse alveolar damage for better understanding.
• Current definition lacks specificity, hindering progress in PGD management.
• Enhanced PGD definitions could facilitate the development of more effective clinical trials.
• Proposed changes may lead to improved understanding of disease pathogenesis.

Abstract