Engineered Covalent Organic Framework Nanomotor for Amplified Cuproptosis Therapy via Wnt/β-catenin Signaling Inhibition

Key Points

• This research aims to enhance cuproptosis therapy through the use of engineered nanomotors targeting Wnt/β-catenin signaling.
• Engineered covalent organic framework nanomotors were developed for drug delivery.
• In vitro experiments assessed the copper ion accumulation in tumor cells.
• Wnt/β-catenin signaling pathway inhibition was evaluated to determine therapeutic effects.
• Significant increase in copper ion accumulation within tumor cells compared to controls (p<0.01).
• Reported therapeutic efficacy improvements with nanomotor application, leading to enhanced cuproptosis.
• Observed inhibition of Wnt/β-catenin signaling correlated with reduced tumor growth.