Objective: To determine whether soybean oil can ameliorate 4-octylphenol-induced alterations in female hormones, minerals, ovarian antioxidants, and inflammatory cytokines in female rats. Methods: Thirty-six female rats were divided into six groups: control, soybean oil (1 mL/rat), soybean oil (2 mL/rat), 4-octylphenol, 4-octylphenol plus soybean oil (1 mL/rat), and 4-octylphenol plus soybean oil (2 mL/rat). Levels of female hormones, serum minerals, ovarian antioxidants, and inflammatory markers were assessed. Ovarian Na + /K + -ATPase activity and nuclear factor kappa B were also detected. Results: Soybean oil restored female hormones, serum minerals, Na + /K + -ATPase activity, and ovarian antioxidants, while lowering ovarian inflammatory markers and nuclear factor kappa B levels in 4-octylphenol-exposed female rats. Moreover, soybean oil upregulated p53 expression while downregulating Bcl-2 expression. Conclusions: Soybean oil treatment improves female hormones, minerals, ovarian oxidative stress and inflammation in 4-octylphenol-exposed rats.
Koriem et al. (Fri,) studied this question.