Abstract Introduction and Rationale There is a large burden of Post Tuberculous Bronchiectasis and cardiovascular disease in developing countries of South Asia. The Coexistence of Cardiovascular Disease in Patients with Post Tuberculous Bronchiectasis is clinically challenging due to the shared risk factors, overlapping symptoms and complex clinical interactions. In spite of a large magnitude of burden of both diseases, there is a large research gap towards understanding the natural history and clinical outcome of Coexistent Cardiovascular Disease in Patients with PostTuberculous Bronchiectasis. Within this background, we conducted this explorative study to examine the clinical implications and impact of the Coexisting Cardiovascular Disease in Patients with Post Tuberculous Bronchiectasis with respect to the clinical outcome. Methods All patients of post tubercular bronchiectasis hospitalized during 1year (March, 2020 -February2021) were enrolled in this Hospital based cross-sectional study conducted at the Department of Pulmonary, Critical Care Sleep Medicine at B.P. Koirala Institute of Health Sciences(BPKIHS), a university teaching hospital in Nepal. Post Tubercular Bronchiectasis was diagnosed as per earlier validated clinical case definition and cardiovascular diseases (CV) was diagnosed combining all clinical, ECG, Echocardiographic and biochemical parameters. A structured proforma recorded socio-demographic variables and clinical spectrum, cardiac events and clinical outcomes. The clinical impact of Coexistent Cardiovascular Disease on clinical spectrum and clinical outcome of Post Tuberculous Bronchiectasis was explored by using descriptive and inferential statistics. Results During the study period of 1 Year, 75 patients of Post tubercular bronchiectasis were enrolled. 58% were Males 70% were in the age group 60-75.85% were Smokers, 70 % had exposure to Indoor air pollution by use of biomass fuels. 48 Patients (65 %) of post tubercular bronchiectasis had co existent cardiovascular disease. Among them (30%) had Systemic Hypertension, (28%) had Congestive Heart Failure, (24 %) had Arrhythmia requiring Pharmacotherapy and (18 %) had ischemic heart disease. 35 % of patients had cardiovascular events during and following an exacerbation. Cardiovascular Disease was more frequent in Elderly Male Smokers with Diabetes, they had more severe disease, required high flow oxygen at hospital, had prolonged hospitalization and poor functional recovery. Conclusions Two third of patients with Post TB bronchiectasis have coexistent cardiovascular disease which caused Double-Burden Clinical Impact with more severe clinical presentation, exacerbation and Prolonged hospitalization. Coexistent Cardiovascular Disease in patients with Post TB Bronchiectasis is clinically relevant, identifiable and modifiable extrapulmonary treatable trait. This Information is clinically useful and has implication for clinical practice. This abstract is funded by: None
Bhatta et al. (Fri,) studied this question.
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