Introduction: Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) and multiple sclerosis (MS) are distinct inflammatory demyelinating disorders that may share overlapping clinical and imaging features, creating important diagnostic challenges. Case Presentation: We describe a 58-year-old woman with unequivocal long-standing relapsing–remitting MS fulfilling established diagnostic criteria, including typical periventricular and deep white matter lesions on magnetic resonance imaging (MRI) and clear dissemination in space and time, with characteristic brain and spinal MRI findings and more than a decade of clinical and MRI stability under extended-interval natalizumab therapy. Following a febrile prodrome, she developed acute severe myelitis with rapid progression from baseline paraparesis (Expanded Disability Status Scale EDSS 6.0) to near-complete paraplegia (EDSS 8.0) within seven days. Cerebrospinal fluid analysis revealed marked pleocytosis, elevated protein levels, and absence of oligoclonal bands, findings atypical for MS relapse. Serum testing demonstrated high-titre MOG immunoglobulin G antibodies, which progressively declined and became negative during follow-up. Retrospective spinal cord MRI revealed transient central grey matter involvement with a characteristic H-sign on axial T2-weighted sequences, consistent with MOGAD-associated myelitis. The patient responded to high-dose intravenous corticosteroids and returned to baseline disability within three months. Conclusion: This case highlights that acute neurological deterioration in patients with established MS should not automatically be attributed to disease reactivation and supports careful consideration of alternative inflammatory demyelinating processes such as MOGAD when clinical, cerebrospinal fluid, and imaging features are atypical. Integration of clinical findings, cerebrospinal fluid analysis, MRI features, and antibody testing is essential to avoid diagnostic anchoring and ensure appropriate management.
Sánchez-Menoyo et al. (Mon,) studied this question.