Early in-hospital cardio-respiratory sleep assessment revealed that sleep apnea (AHI > 15/h) was present in 89% of patients with acute coronary syndrome, predominantly as central apneas.
Observational (n=49)
What is the prevalence and characteristics of sleep apnea in patients with acute coronary syndrome within the first 48 hours of admission?
Sleep apnea is highly prevalent in the acute phase of ACS and is predominantly characterized by central apneas, which correlate with structural cardiac changes.
Abstract Aim Sleep apnea (SA) is highly prevalent condition inpatients with cardiovascular diseases. The aim of the study was to determine the prevalence and characteristics of sleep-disordered breathing in patients with acute coronary syndrome in first 48 hours after hospital admission. Preliminary data. Material and Methods 49 patients (70% male) with confirmed ACS (97% ST-elevation myocardial infarction) were included. All patients received standard guideline-directed ACS therapy. Cardio-respiratory sleep study was performed within the first 48 hours of admission in the intensive care unit (ICU). Results The mean age was - 61 54;69 years, ejection fraction 55 49;59%, BMI 29,3 26,4; 33,4 kg/m2. Daytime SpO2 - 97 97-98%, systolic blood pressure (SBP) 120 110;130 mmHg, diastolic BP (DBP) 76 70-81,5 mmHg. Sleep apnea (apnea-hypopnia index AHI 15/h) was present in 89% of patients, severe SA (AHI 30/h) - 65%. Mean AHI - 45,9 21,4; 62,6/h, mean oxygen desaturation index (ODI) 34,0 15,7; 51,8/h, mean SpO2 - 95 94; 96%, min SpO2 - 82 79,0; 87,0%. Mean obstructive AHI - 6,8 2,8; 11,6/h, mean central AHI - 15,0 3,9; 40,1/h. Obstructive AHI 15/h - was found in 19,6% of patients, central AHI 15/h - occurred in 47,8% of patients. No correlations were found between: central apnea index and ejection fraction (p = 0,417), central AHI and morphine (p = 0,990), ticagrelor (p = 0,720), AHI and BMI (p = 0,199). Significant correlations were found between: maximal central apnea duration and mean right atrium area (r = 0,45, p = 0,002), indexed left atrium volume (r = 0,41, p = 0,007); mean duration of obstructive apnea and pulmonary artery systolic pressure (r = 0,35, p = 0,037); time SpO2 90% and troponin (r = 0,31, p = 0,045) and indexed left atrium volume (r = 0,337, p = 0,02). Conclusion sleep apnea is highly prevalent in patients with ACS in first 48 hours after admission and is predominantly characterized by central apneas. Sleep apnea is associated with structural cardiac changes, particularly involving atrial enlargement and elevated pulmonary pressure. This abstract is funded by: None
Elfimova et al. (Fri,) conducted a observational in Acute coronary syndrome (n=49). Cardio-respiratory sleep study was evaluated on Prevalence of sleep apnea (AHI > 15/h). Early in-hospital cardio-respiratory sleep assessment revealed that sleep apnea (AHI > 15/h) was present in 89% of patients with acute coronary syndrome, predominantly as central apneas.