Body mass index category was not significantly associated with disease severity as determined by REVEAL 2.0 risk stratification in patients with pulmonary arterial hypertension (p=0.677).
Cross-Sectional (n=175)
No
Does BMI category associate with disease severity risk in patients with pulmonary arterial hypertension?
BMI category is not significantly associated with disease severity as determined by the REVEAL 2.0 risk score in patients with pulmonary arterial hypertension.
p-value: p=0.677
Abstract Rationale Body mass index (BMI) has demonstrated prognostic relevance across multiple cardiovascular conditions. However, its association with disease severity in pulmonary arterial hypertension (PAH) remains uncertain. The REVEAL 2.0 risk calculator provides a validated, multidimensional framework for estimating mortality risk in PAH. Determining whether BMI independently correlates with risk stratification could enhance patient assessment and management. Methods We performed a cross-sectional analysis of 175 patients with PAH to evaluate the relationship between BMI category and REVEAL 2.0 risk score classification. Patients were categorized as underweight (n = 3), normal weight (18.5-24.9 kg/m²; n = 44), overweight (25.0-29.9 kg/m²; n = 49), or obese (≥30 kg/m²; n = 79). REVEAL 2.0 scores classified patients into low- (n = 77), intermediate- (n = 31), or high-risk (n = 67) groups. Associations between BMI category and risk stratification were evaluated using chi-square analysis. Results Risk distribution varied numerically across BMI groups. Among normal-weight patients, 45.5% were low risk, 18.2% intermediate risk, and 36.4% high risk. Overweight patients showed 40.8% low, 14.3% intermediate, and 44.9% high risk. Obese patients demonstrated 46.8% low, 19.0% intermediate, and 34.2% high risk. The three underweight patients were distributed as 0% low, 33.3% intermediate, and 66.7% high risk. The association between BMI and REVEAL 2.0 risk category was not statistically significant (χ² = 3.996, df = 6, p = 0.677). Conclusions In this single-center cohort of patients with PAH, BMI category was not significantly associated with disease severity as determined by REVEAL 2.0 risk stratification. Although numerical differences in risk distribution were observed, they did not reach statistical significance. These findings suggest that BMI alone may not serve as a robust indicator of PAH severity when assessed alongside comprehensive, multivariable risk models. Larger, prospective studies are warranted to explore whether baseline BMI or longitudinal BMI changes influence clinical outcomes in PAH. This abstract is funded by: None
Fernandez et al. (Fri,) conducted a cross-sectional in Pulmonary arterial hypertension (PAH) (n=175). Body mass index (BMI) category vs. Across BMI categories (underweight, normal weight, overweight, obese) was evaluated on REVEAL 2.0 risk score classification (p=0.677). Body mass index category was not significantly associated with disease severity as determined by REVEAL 2.0 risk stratification in patients with pulmonary arterial hypertension (p=0.677).