New-onset pulmonary embolism after cancer diagnosis significantly increased the incidence of MACCE compared to cancer patients without PE (69.57% vs. 30.76%; p < 0.001).
Cohort (n=500,876)
Does new-onset pulmonary embolism after cancer diagnosis increase the risk of major adverse cardiac and cerebrovascular events compared to cancer patients without pulmonary embolism?
New-onset pulmonary embolism after a cancer diagnosis is associated with a significantly increased long-term risk of major adverse cardiac and cerebrovascular events, mortality, heart failure, and stroke.
Absolute Event Rate: 69.57% vs 30.76%
p-value: p=<0.001
Abstract Rationale Patients with cancer are at increased risk for pulmonary embolism (PE), which is associated with significant morbidity and mortality. However, the long-term cardiovascular outcomes of cancer patients who subsequently develop PE remain inadequately characterized. Objectives To investigate the long-term cardiovascular outcomes of patients with new-onset PE after cancer diagnosis, specifically major adverse cardiac and cerebrovascular events (MACCE). Methods We conducted a prospective cohort analysis using data from 500,876 participants in the UK Biobank, stratifying into four groups: no cancer/no PE (n = 425,328), no cancer/PE (n = 6,675), cancer/no PE (n = 65,486), and cancer before PE (n = 2,714). Kaplan-Meier curves were constructed for survival analysis, and multivariate Cox regression was applied to determine hazard ratios (HRs) adjusted for key demographic and clinical factors. Results Over an average follow-up of 12.99 years, the incidence of MACCE was significantly higher among patients with new-onset PE after cancer diagnosis (69.57%), compared to cancer patients without PE (30.76%; p 0.001). Mortality (62.45% vs. 24.76%), heart failure (8.14% vs. 3.63%), stroke (5.71% vs. 2.83%), and bleeding events (9.14% vs. 5.60%) were all significantly increased in the PE group. Multivariate Cox regression analysis identified specific cancer type, including pancreatic, lung, colon rectum and kidney/renal/pelvis, as well as baseline factors including age at diagnosis of cancer, obesity, and Townsend deprivation index, as significant independent risk factors for developing PE among cancer patients. Conclusion New-onset PE after cancer diagnosis significantly worsens long-term cardiovascular outcomes, highlighting the critical need for vigilant cardiovascular monitoring and tailored preventive strategies in oncology care, particularly for patients with high-risk cancers. This abstract is funded by: National Natural Science Foundation of China (82400483, 82100409)
Zhang et al. (Fri,) conducted a cohort in New-onset pulmonary embolism after cancer diagnosis (n=500,876). New-onset PE after cancer diagnosis vs. Cancer patients without PE was evaluated on Major adverse cardiac and cerebrovascular events (MACCE) (p=<0.001). New-onset pulmonary embolism after cancer diagnosis significantly increased the incidence of MACCE compared to cancer patients without PE (69.57% vs. 30.76%; p < 0.001).