New fused tetracyclic ring systems: synthesis of 1-thia-4 a ,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

Key Points

• This research aims to synthesize new tetracyclic compounds and evaluate their antimicrobial properties.
• Utilized a multicomponent strategy for the synthesis of 1-thia-4a,11,12-triazatetracenes.
• Performed structural confirmation using 2D-HMBC techniques.
• Conducted molecular docking studies to support antimicrobial activity.
• Compound 9a showed promising broad-spectrum antimicrobial activity.
• Molecular docking studies indicated strong binding affinity for target pathogens.