What question did this study set out to answer?

This research aims to characterize the genome of Streptomyces globosus OSY-MM and its antimicrobial potential.

May 20, 2026Microbiology Resource Announcements0 citationsOpen Access

Draft genome of Streptomyces globosus OSY-MM, a broad-spectrum antimicrobial producer isolated from a cave in South Central Kentucky

GGGabriella J. Gephart AAAhmed G. Abdelhamid MMMatthew J. Mezydlo

Key Points

This research aims to characterize the genome of Streptomyces globosus OSY-MM and its antimicrobial potential.
Isolated S. globosus OSY-MM from cave soil in South Central Kentucky.
Sequenced the genome resulting in 7,277,920 bp with 6,476 genes.
Identified biosynthetic gene clusters related to antibiotic production.
Demonstrated broad-spectrum antimicrobial activity of S. globosus OSY-MM.
Identified key biosynthetic gene clusters for streptothricin, kirromycin, and venezuelin-like antibiotics.

Abstract

ABSTRACT Streptomyces globosus OSY-MM was originally isolated from a soil sample collected from a cave in South Central Kentucky and was found to display strong, broad-spectrum antimicrobial activity. S. globosus OSY-MM has a 7,277,920 bp genome with 6,476 genes, including biosynthetic gene clusters encoding the production of streptothricin, kirromycin, and venezuelin-like antibiotics.

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