Microinjection molded PLA/ZnO-TiO 2 composites with in situ fibrillation: achieving mechanical matching cortical bone and enhanced osteoinduction

Key Points

• This research aims to enhance the osteogenic properties of PLA-based composites using ZnO and TiO2.
• ZnO nanoparticles were anchored to fibrous TiO2 substrates using hydrothermal deposition.
• Microinjection molding was employed to create PLA/ZnO-TiO2 composites.
• The study assessed mechanical matching and bioactivity of the resulting composites.
• Incorporation of ZnO led to a significant increase in the bioactivity of PLA-based devices.
• The enhanced composites demonstrated superior osteogenic capability compared to standard PLA.
• Mechanical properties were improved, matching those of cortical bone.