Mechanistically Orthogonal Radical Strategies Converging on Programmable Site-Selective Halogenation of Quinoxalinones

Key Points

• To investigate reagent-programmed site-selective halogenation of quinoxalinones through different radical pathways.
• Utilized a sunlight-driven PDI photoredox system to activate inorganic halides.
• Implemented moisture-assisted radical pathways for halogenation.
• Converged on identical halogenated quinoxalinone products.
• Achieved C3-, C6-, and C7-halogenation of quinoxalinones.
• Demonstrated effective conversion with high selectivity to the desired products.