Chlorhexidine-miconazole-loaded iron oxide nanoparticles inhibit denture stomatitis biofilms in vitro

Key Points

• This research aims to evaluate the effectiveness of chlorhexidine-miconazole-loaded iron oxide nanoparticles against denture stomatitis biofilms.
• Developed chitosan-coated iron oxide nanoparticles as a dual-nanocarrier for chlorhexidine and miconazole.
• Assessed the impact of these nanoparticles on biofilms mimicking denture stomatitis conditions in vitro.
• Demonstrated significant inhibition of denture stomatitis biofilm formation by the dual-nanocarrier system.
• Showed improved biofilm reduction compared to using chlorhexidine or miconazole alone.