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This research aims to compare the efficacy of different TMS coil types in treating comorbid major depressive disorder, generalized anxiety disorder, and obsessive-compulsive disorder.

May 21, 2026Transcranial magnetic stimulation .0 citationsOpen Access

Comparison of the Transcranial Magnetic Stimulation (TMS) With Figure-Of-8 Coil Focal TMS Over the Supplementary Motor Area (SMA) and Dorsolateral Prefrontal Cortex Sites Vs. Double Cone Coil (DCC) TMS Over the Dorsomedial Prefrontal Cortex (DMPFC) Treatment in Treating Patients With Comorbid MDD, GAD, and OCD

RPRandy Pardell SSSabrina Samoza MSMia Scholl

Key Points

This research aims to compare the efficacy of different TMS coil types in treating comorbid major depressive disorder, generalized anxiety disorder, and obsessive-compulsive disorder.
Used a non-parametric ANOVA (Kruskal-Wallis test) for analysis of outcome differences based on time intervals between TMS courses.
Reported outcomes for two treatment courses, including non-responders, responders, and remitters.
Course one outcomes: 9 non-responders, 14 responders, 12 remitters; course two outcomes: 12 non-responders, 10 responders, 13 remitters.
No significant differences found in outcomes related to time intervals (p=0.36).
Repeat TMS shows consistent efficacy, supporting its use for recurrent depressive episodes.

Abstract

effect of time interval (weeks) between courses among outcome groups, we used a non-parametric ANOVA (Kruskal-Wallis test).Results: Overall outcomes for course one were: non-responders =9, responders =14, remitters =12.For course two outcomes were: non-responders =12, responders =10, remittera=13.Whereas the number of non-response patients increased slightly during the second TMS course, chi-squared results revealed these differences were not significant (p=0.30).Non-parametric ANOVA analysis revealed no statistically significant difference across outcome groups based on the time between courses (p=0.36).Discussion: TMS outcomes show similar efficacy in repeat courses.The time interval between courses appears not to affect outcomes.These findings suggest that TMS efficacy does not diminish in a second treatment course.This supports repeat TMS as a viable and highly-effective early treatment option for patients with recurrent depressive episodes, regardless of time interval.

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Abstract

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