Adiposity-based obesity classification and cardiometabolic and kidney outcomes: a longitudinal UK Biobank analysis

Key Points

• This analysis aims to evaluate the prognostic value of an adiposity-based classification combining body fat percentage and waist circumference for cardiometabolic and kidney outcomes.
• Classified 489,311 UK Biobank participants into five risk groups based on body fat percentage and waist circumference.
• Identified associations with major adverse cardiovascular events, type 2 diabetes, and chronic kidney disease using Cox proportional hazards models.
• Visualized comparison with BMI categories using an alluvial plot.
• 24,778 participants experienced major adverse cardiovascular events (5.1%) over 13.1 years, with higher risks in Groups 4 and 5.
• Age- and sex-adjusted HR for T2D was 9.23 (95% CI 8.70-9.83) in Group 5 vs. reference Group 1.
• Notable discordance: 32.6% of individuals in high-risk Group 5 had a BMI in the normal-to-overweight range.