Abstract Objectives This study aimed to compare serum neopterin and other inflammatory marker levels between patients with rosacea and healthy controls and to investigate the potential role of neopterin in disease diagnosis and severity assessment. Methods Forty drug-naive patients clinically diagnosed with papulopustular rosacea and forty healthy controls were included. The serum levels of neopterin and other inflammatory markers were measured. The Investigator’s Global Assessment (IGA) score was used to assess the patient’s disease severity. Results Serum neopterin, TNF-α, IFN-γ, and CRP levels were significantly higher in patients with papulopustular rosacea than in controls. A positive correlation was found between neopterin, TNF-α, IFN-γ, and IGA scores (r=0.498, 0.523, and 0.432, respectively). ROC curve analysis demonstrated good diagnostic performance for IFN-γ (AUC=0.821), TNF-α (AUC=0.780), and neopterin (AUC=0.747). Conclusions New biochemical markers are needed to assess rosacea severity. Neopterin may be a potential biomarker for rosacea.
Ünal et al. (Thu,) studied this question.