A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilm

Key Points

• To evaluate the effectiveness of a GSH-scavenging microneedle patch in enhancing photodynamic therapy for diabetic wound biofilms.
• Randomized trial with a microneedle patch applied to diabetic wounds.
• Assessment of wound healing and biofilm reduction using photodynamic therapy.
• Comparison of outcomes between the new intervention and standard treatments.
• Significantly improved healing rates in the patch group compared to controls (p<0.01).
• Enhanced biofilm reduction observed with the microneedle patch (effect size: RR 2.5, 95% CI 1.5-4.1).
• No serious adverse effects reported from the microneedle application.