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-weighted MR contrast enhancement; Cy7 fluorescence increase achieving tumor-to-background ratio in NIRF imaging. In orthotopic and metastatic breast cancer models, the nanoprobes enabled high-resolution visualization of primary tumors and lung metastases as small as a diameter of 0.3 mm. In addition, the novel molecular imaging probe demonstrated favorable biosafety and efficient renal clearance, supporting the potential for clinical translation. This work establishes a tumor stroma-targeted activatable platform advancing metastasis-sensitive diagnosis and providing a blueprint for microenvironment-responsive theranostics.
Wang et al. (Tue,) studied this question.