FeSO4-Vitamin C co-loaded active targeting liposome inhibits liver cancer through synergistic ferroptosis mechanism

Key Points

• The study aims to evaluate the synergistic effects of FeSO4 and Vitamin C co-loaded liposomes on liver cancer via ferroptosis mechanisms.
• Developed a liposome formulation integrating Fe2+ and Vitamin C for enhanced targeting.
• Evaluated the oxidative stress response and ferroptosis in liver cancer cell lines using the new formulation.
• Increased intracellular delivery of Fe2+ and Vitamin C was observed, leading to elevated oxidative stress levels.
• Enhanced liver cancer cell death was noted due to the synergistic effect of Fe2+ and Vitamin C, promoting ferroptosis.