Combined Electrospun Fibre-Microneedle Patches for Enhanced Transmucosal Delivery of Benzodiazepines and Proteins

Key Points

• This research investigates the effectiveness of combined electrospun fibre-microneedle patches for delivering benzodiazepines and proteins through the oral mucosa.
• Utilized electrospun mucoadhesive patches for drug application.
• Assessed the patches' ability to penetrate the epithelial barrier for enhanced drug delivery.
• Evaluated both benzodiazepines and protein compounds for systemic absorption.
• The electrospun patches significantly increased drug uptake into systemic circulation compared to traditional methods.
• Demonstrated effective transport rates beyond first-pass metabolism for both benzodiazepines and proteins.