ABSTRACT Objective Trigeminal trophic syndrome ( TTS ) is a rare condition caused by trigeminal nerve injury, classically characterized by anaesthesia, paresthesia and facial ulceration. We present two cases of TTS successfully managed with regional nerve blocks and onabotulinumtoxinA . Methods Two patients—a 54‐year‐old woman and a 65‐year‐old man—with a history of facial ulceration and pain were evaluated for suspected trigeminal neuralgia. Results Both patients were treated with ropivacaine nerve blocks targeting the affected sensory branches of the trigeminal nerve, repeated every 2–3 months. They reported immediate and sustained pain relief following treatment. One patient also received onabotulinumtoxinA injections, which led to further symptomatic improvement. Discussion TTS should be considered in patients presenting with unilateral facial ulceration and sensory disturbances. Trigeminal nerve blocks, with ongoing follow‐up, may offer significant symptomatic relief. OnabotulinumtoxinA may serve as a useful adjunct treatment in select cases.
Masrour et al. (Wed,) studied this question.