Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model

Key Points

• To investigate the effects of acute wood smoke exposure on hippocampal gene expression in an accelerated ovarian failure mouse model.
• Examined hippocampal responses following acute wood smoke exposure in mice with ovarian hormone deficiency.
• Analyzed transcriptional changes in neuronal and glial populations specifically.
• Identified distinct changes in synaptic and immune pathways.
• Neuroinflammatory and oxidative stress markers were significantly upregulated post wood smoke exposure.
• Distinct synaptic pathways were altered in neuronal cells, while unique immune responses were noted in glial cells.
• These findings highlight the differential impact of wood smoke on hippocampal cell types under estrogen deficiency.