USP13 stabilizes EPHA2 to promote M2 macrophage polarization and cervical cancer progression

Key Points

• This research explores how USP13 contributes to the stabilization of EPHA2 and its role in M2 macrophage polarization in cervical cancer progression.
• Analyzed the interaction between USP13 and EPHA2, focusing on the deubiquitination process.
• Examined the effects of USP13 on M2 macrophage polarization and cervical cancer cell behavior in vivo.
• USP13 significantly stabilizes EPHA2, enhancing M2 macrophage polarization.
• In vivo studies show increased tumor growth linked to the USP13/EPHA2 axis.