What question did this study set out to answer?

This study aims to investigate the role of KDM6A in chondrocyte-to-osteoblast transdifferentiation and fracture healing through Wnt/beta-catenin pathway activation.

June 1, 2026International Journal of Molecular Medicine0 citationsOpen Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

YRYi Rong HYHao Yu HYHeng Yin

Key Points

This study aims to investigate the role of KDM6A in chondrocyte-to-osteoblast transdifferentiation and fracture healing through Wnt/beta-catenin pathway activation.
Used KDM6A-knockout mice to evaluate osteogenic defects and fracture healing.
Compared outcomes with control mice to assess differences in bone regeneration and transdifferentiation activity.
KDM6A-knockout mice showed significant osteogenic defects and delayed fracture healing compared to controls.
Activation of the Wnt/beta-catenin pathway was shown to be critical for KDM6A's role in these processes.

Abstract

, KDM6A‑knockout mice exhibited osteogenic defects and delayed fracture healing compared with control mice. KDM6A serves as a pivotal oxygen sensor that drives CH‑to‑osteoblast transdifferentiation and enhances fracture healing through Wnt/β‑catenin pathway activation. The KDM6A‑mediated oxygen response mechanism is a potential target for enhancing bone regeneration during fracture repair.

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Cite This Study

Rong et al. (Thu,) studied this question.

synapsesocial.com/papers/6a1d20f302fbce913063724f https://doi.org/https://doi.org/10.3892/ijmm.2026.5874

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