Triterpenoid saponins from Caragana korshinskii Kom.: α ‑glucosidase inhibitory activity and characterisation of four new compounds

Key Points

• The aim is to investigate the alpha-glucosidase inhibitory activity of triterpenoid saponins from Caragana korshinskii.
• Characterization of four newly identified triterpenoid saponins from Caragana korshinskii
• Assessment of their inhibitory activity against alpha-glucosidase
• Evaluation of structural modifications such as glucuronosyl substitution and hydroxylation
• The identified triterpenoid saponins exhibit significant alpha-glucosidase inhibitory activity
• Glucuronosyl substitution at C-3 and hydroxylation at C-23 decrease inhibitory potency
• Concentration-dependent inhibition was observed for the most potent saponins