Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs

Key Points

• The research aims to develop a fluorinated neuromuscular blocking agent with enhanced activity and biosafety.
• Investigated the activity profile of fluorinated agents for neuromuscular blockade and reversal.
• Conducted assessments on the safety and efficacy of these agents in a controlled environment.
• Demonstrated significant improvements in blockade duration and safety compared to traditional agents.
• Established a viable framework for on-demand reversal of neuromuscular blockade.