PROCON Study: Preventive Antiepileptic Treatment in Supratentorial Neurosurgery – A Retrospective Before–After Analysis of a Change in Clinical Guidelines

Key Points

• This study aims to evaluate the impact of changing clinical guidelines for antiepileptic drug prophylaxis during supratentorial neurosurgery.
• Conducted a retrospective before-after analysis of seizure incidence following changes in clinical guidelines.
• Monitored postoperative seizure incidence and functional autonomy outcomes in patients undergoing supratentorial craniotomy.
• Postoperative seizure incidence after surgery was 5.5%.
• Stopping prophylactic antiepileptic drugs did not increase the seizure incidence compared to prior guidelines.
• Adverse events related to antiepileptic drugs occurred in 1.5% of patients.