What is the clinical evidence from this study?

Study design: Cohort. Population: Incident heart failure (n=57156). Intervention: Highest quartile of cumulative atherogenic index of plasma (cum-AIP) vs. Lowest quartile of cum-AIP. Primary outcome: Incident heart failure (HR 1.769, 95% CI 1.512-2.069, p=< 0.0001).

What question did this study set out to answer?

The study aims to analyze how cumulative exposure to the atherogenic index of plasma correlates with the risk of developing heart failure.

June 1, 2026International Heart Journal0 citationsOpen Access

Relationship Between the Cumulative Atherogenic Index of Plasma Exposure and Incident Heart Failure

Q: What are the key findings of this study?

Individuals in the highest quartile of cumulative atherogenic index of plasma exposure had a significantly elevated risk of incident heart failure compared to those in the lowest quartile (HR 1.769).

Q: What question did this study set out to answer?

The study aims to analyze how cumulative exposure to the atherogenic index of plasma correlates with the risk of developing heart failure.

LTLiying Tian QQQi Qi XWXinyu Wu

Key Result

Individuals in the highest quartile of cumulative atherogenic index of plasma exposure had a significantly elevated risk of incident heart failure compared to those in the lowest quartile (HR 1.769).

Key Points

The study aims to analyze how cumulative exposure to the atherogenic index of plasma correlates with the risk of developing heart failure.
Characterized the relationship between cumulative atherogenic index of plasma exposure and heart failure incidence
Focused on a Chinese population
Utilized statistical analysis to assess risk factors.
Higher cumulative atherogenic index of plasma exposure is associated with an increased risk of heart failure
Specific risk metrics and statistical data not fully disclosed in abstract.

Study Design

Type

Cohort (n=57,156)

Structured PICO

Does cumulative exposure to atherogenic index of plasma (AIP) affect the risk of incident heart failure in a Chinese population?

Population

Chinese population

Intervention

Cumulative exposure to atherogenic index of plasma (AIP)

Outcome

Incident heart failure (HF)hard clinical

This study aims to characterize the relationship between cumulative atherogenic index of plasma exposure and the risk of incident heart failure.

Main Result

Effect estimate: HR 1.769 (95% CI 1.512-2.069)

Absolute Event Rate: 2.61% vs 1.55%

p-value: p=< 0.0001

Limitations

Incident HF cases were not differentiated by etiology (ischemic versus non-ischemic).
Classes and stages of HF were not documented.
Potential misclassification of LVEF due to the evolution of echocardiographic equipment and temporal drifts among readers.
Low rate of hypolipidemic drug use and adjustment of medication use as only a binary covariate may leave substantial residual confounding.
Cum-AIP requires several longitudinal lipid assessments over years, making it not easily accessible in standard clinical practice.

Abstract

We aimed to characterize the relationship between cumulative exposure to atherogenic index of plasma (AIP) and the risk of incident heart failure (HF) in a Chinese population.

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