Enantioselective Construction of Cyclopentene Spiroindene Scaffolds via Phosphine-Catalyzed Annulation of Benzofulvene with MBH Carbonates

Key Points

• This research aims to develop a chiral amide-phosphine catalyst for the enantioselective synthesis of cyclopentene spiroindenes.
• Developed a novel chiral amide-phosphine bifunctional catalyst.
• Conducted asymmetric intermolecular vinylogous [3+2] annulations with MBH carbonates and benzofulvenes.
• Analyzed regioselectivity and stereoselectivity of the reaction products.
• Achieved excellent regioselectivity (>20:1 dr) and stereoselectivity (>99% ee) in product formation.
• Demonstrated the efficacy of the bifunctional catalyst in synthesizing complex chiral compounds.