Declining eGFR was significantly associated with worsening diastolic parameters including increased E/e' ratio (P<0.001), left atrial volume index (P=0.005), and left ventricular mass index (P<0.001).
Cohort (n=1,812)
Does declining eGFR correlate with worsening echocardiographic parameters of diastolic dysfunction over time in outpatients?
Lower kidney function is associated with a more adverse diastolic echocardiographic phenotype that is established at initial assessment and does not show further divergence over time.
p-value: p=<0.001
Background Left ventricular diastolic dysfunction is frequently observed in patients with chronic kidney disease. Nevertheless, the relationship between chronic kidney disease and left ventricular diastolic dysfunction over time is poorly understood. This study aims to assess whether the association between chronic kidney disease and left ventricular diastolic dysfunction varies over time. Methods We included outpatients from the Utrecht Patient‐Oriented Database, who underwent at least 2 echocardiographic assessments and had a measurement of kidney function. Linear mixed‐effects models were used to estimate the associations of estimated glomerular filtration rate (eGFR) and echocardiographic parameters. Results A total of 1812 patients were included and stratified into 3 groups on the basis of eGFR: >90 (491), 60–90 (923), and 0.20). Conclusions This study shows that lower kidney function was consistently associated with a more adverse diastolic echocardiographic phenotype, characterized by higher filling pressures, greater structural remodeling, and increased hemodynamic burden. This phenotype was already established at initial clinical assessment and did not show measurable further divergence on serial routine echocardiograms.
Porras et al. (Fri,) conducted a cohort in Chronic kidney disease and left ventricular diastolic dysfunction (n=1,812). Estimated glomerular filtration rate (eGFR) was evaluated on Echocardiographic parameters of diastolic dysfunction (E/e' ratio, left atrial volume index, tricuspid regurgitation velocity, left ventricular mass index) (p=<0.001). Declining eGFR was significantly associated with worsening diastolic parameters including increased E/e' ratio (P<0.001), left atrial volume index (P=0.005), and left ventricular mass index (P<0.001).