Sedation strategies incorporating remimazolam-dexmedetomidine protocol for pulsed-field ablation of atrial fibrillation

Key Points

• The study aims to evaluate sedation strategies using a remimazolam-dexmedetomidine protocol during pulsed-field ablation for atrial fibrillation.
• Randomized trial comparing sedation protocols for pulsed-field ablation.
• Participants were administered either remimazolam-dexmedetomidine or standard sedation.
• Outcomes were assessed regarding sedation quality and ablation success.
• The remimazolam-dexmedetomidine group achieved a higher sedation quality rating (p<0.05).
• Ablation success rates were improved with the remimazolam-dexmedetomidine protocol (OR 1.8, 95% CI 1.3-2.5, p<0.01).
• Fewer adverse events were reported in the new sedation group (p=0.03).