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Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are independent cardiovascular risk factor in the general population. Genetic factors and viral infections have been linked to AAA1 occurrence. We studied the association between environmental pollution and AAA1 response and their relationship with years of life lost or gained (YPLLG). Methods: levels, and proximity to polluted sites. Results: < 0.001), even after adjustments. Conclusions: While causal inference cannot be drawn due to the cross-sectional design, AAA1 hotspots overlapped regions of higher air and soil pollution and reduced life expectancy. Determining causality and whether specific pollutants amplify the AAA1 response will be key to validate these hypothesis-generating findings.
Fellay et al. (Thu,) studied this question.