Determinants of Simulated Dissolution Profile Similarity (f2): Interactions of Z-Factor, Particle Size, Dose, Solubility, and Diffusivity

Key Points

• The research aims to determine how interactions between Z-factor, particle size, dose, solubility, and diffusivity affect the similarity of dissolution profiles.
• Evaluated various particle sizes under controlled biorelevant dissolution conditions.
• Analyzed the impact of dose, solubility, and diffusivity on dissolution profile similarity.
• Findings highlight the importance of considering particle size specifications in relation to both solubility and diffusivity for improving dissolution profile similarity.