Hydroxyl-radical-specific cascade photogeneration for oxygen-chain photocatalytic therapy

Key Points

• To investigate a novel method for generating hydroxyl radicals specifically in photocatalytic therapy.
• Developed a hydroxyl-radical-specific cascade method for photogeneration.
• Compared the efficacy of this method against conventional approaches under controlled conditions.
• Analyzed the impact on reactive oxygen species production during the therapy.
• Significantly higher •OH production observed with the new method (p<0.01).
• Enhanced therapeutic effects were noted in treatment protocols using the cascade method compared to traditional ones.
• Reduction in tumor size was more pronounced with the hydroxyl-radical-specific approach.